GABA, which is short for gamma-aminobutyric acid, is the primary inhibitory neurotransmitter. Its primary role is to calm the brain, slow things down, and relax you.
- Reduces stress really fast because it crosses the blood-brain barrier and helps to deactivate stress hormones (thereby reducing anxiety).
- Relaxes your muscles like a natural Valium.
- Levels of GABA drop during PMS.
- Too much GABA can make you drowsy.
- GABA helps to regulates muscle tone.
- Mental Focus
- Regulation of Sleep
- Body Temperature
- Sexual Arousal and Desire
- Action of the Pituitary
- Action of the Autonomic Nervous System (Stress Response System)
- Stiff and/or Tense Muscles
- Unable to Relax
- Anxiety and Panic Disorders
- Muscle Spasms
- Aggressive Behavior
- GERD as it is needed to help regulate the lower part of the esophagus
- Decreased Eye Contact
- Anti-Social Behavior
- Attention Deficit Disorder
- Problems with Eye-Focusing (as seen in autistic children when both eyes are focused inward towards the nose or waver back and forth in a horizontal or vertical movement)
- Chronic Pain Syndromes
Addictive Substances Used
- Monosodium Glutamate (MSG)
Body Systems, Glands & Organs Affected
- Colon / Bowel
- Gastrointestinal Tract
- Vitamin K1
- Vitamin K2
- Whole Wheat (Whole Grain)
- Beef Liver
- The scent of jasmine (a substance frequently used in aromatherapy) may help enhance the effects of GABA.
- A study published in the Journal of Biological Chemistry in 2010 indicates that people with major depression may be more likely to have low levels of GABA.
- The primary role of the hypothalamus is to maintain homeostasis throughout the body, and without enough GABA production, this will not happen.
- GABA binds to sub-receptors and activates secondary messengers that affect dopamine.
- When GABA is low, glutamate is high and vice versa.
- If there is an excess of calcium in the body for any reason, it too will disrupt the GABA balance.
- Depletion of GABA can be a major contributing factor to sympathetic nervous system dominance and the many associated conditions like:
- Adrenal Fatigue
- Chemical Sensitivities
- Chronic Fatigue
- Panic Attacks
- Anxiety Disorders
- Progesterone increases the level of GABA in the human body.
- GABA supplements are considered to be likely safe when taken by mouth for a timeframe as determined by your Medical Doctor and/or Naturopathic Doctor.
- Pregnant and breastfeeding women should avoid GABA.
Ross, J. (2000). The diet cure: the breakthrough programme to rebalance your body chemistry, end food cravings and achieve your natural ideal weight – now! London: Michael Joseph.
GABA. (n.d.). Retrieved February 06, 2021, from (NOTE: Upon inquiry, link broken was found to be broken on 09/08/2021) http://healthyfoods.org/2011/03/28/gaba/.
Health, J. (2018, January 01). Foods high in Gaba to boost your Brain [Increase Gaba naturally]. Retrieved February 06, 2021, from https://optinghealth.com/foods-high-in-gaba.
Wang ZJ, Heinbockel T. Essential oils and their constituents targeting the GABAergic system and sodium channels as treatment of neurological diseases. Molecules. 2018;23(5):1061. doi:10.3390/molecules23051061.
Sergeeva OA, Kletke O, Kragler A, et al. Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors. J Biol Chem. 2010;285(31):23985‐23993. doi:10.1074/jbc.M110.103309.
Datis Kharrazian. Why Isn’t My Brain Working?: A revolutionary understanding of brain decline and effective strategies to recover your brain’s health. Carlsbad California. Elephant Press (2013).
Möykkynen, Uusi-Oukari M, Heikkilä J, et.al. Magnesium potentiation of the function of native and recombinant GABA(A) receptors. Neuroreport. 2001 Jul 20;12(10):2175-9.